Epidermal growth factor (EGF) is a 6 kilodalton protein belonging to the EGF-protein family. EGF binds to the epidermal growth factor receptor (EGFR) and stimulates cell growth and differentiation. In humans, this protein is made of 53 amino acid residues and its tertiary structure is held together by 3 intramolecular disulfide bonds. Researchers first identified EGF in human urine and mice submaxillary glands as a secreted protein. Since then, EGF has been found in tears, saliva, milk, plasma, and tissues, including the parotid gland and submandibular gland-urogastrone or its trade name Heberprot-P.
Epidermal Growth Factor (EGF) also known as urogastrone is a small polypeptide (6 kilodalton) secreted by certain epithelial cells in the digestive tract, salivary glands, mammary glands and kidney. EGF may play several roles in human tissue growth and cell differentiation. Epidermal growth factor stimulates angiogenesis and epithelial cell growth. This polypeptide is found in tears, saliva, and milk, where it acts as a regulator of the immune system and an anti-inflammatory agent, egf growth factor activates multiple pathways related to carcinogenesis, including mitogenic signaling via protein kinase A (PKA), extracellular signal-regulated kinases 1 and 2 (ERK1/2), phosphatidylinositol 3-kinase (PI3K) cascades, nuclear factor-kappaB (NF-kappaB) pathway and mitogen-activated protein kinase cascade activation.
We are a NorthEast BioLab with 15 years experience in providing small and large molecule bioanalysis for clinical, preclinical, and drug discovery studies. Our team has an excellent track record of advancing Pharmacokinetics (PK), Bioavailability and Bioequivalence (BA/BE), Toxicokinetics (TK), Immunogenicity (ADA), Biomarker Testing, Custom Assays and Method Development/Validation using LC-MS/MS technology. We offer Glip/Gclp compliant, FDA audited and DEA & CT State Schedule II-IV approved facility.
NorthEast BioLab is a world-class bioanalytical lab that offers a complete range of testing services to support your specific requirements. We offer complete turnkey solutions for all projects, from initial bioanalytical investigations, method development and validation using LC-MS/MS, ELISA, MSD ECL, Luminex Multiplex, Western Blot and qPCR methods to analytical data review and submission.
With a focus on giving you the quality and data you need for your drug development programs, our experienced team has unparalleled knowledge about quality bioanalytical testing. We offer comprehensive method development, validation and project management services to pharmaceutical companies globally.
NorthEast biolab is your one-stop shop for bioanalytical services and custom assays. We offer high quality LC-MS/MS, ELISA, MSD ECL, Luminex Multiplex, Western Blot, and qPCR methods as well as analyses of immunogenicity testing and biomarkers. Our experienced team has an excellent track record of advancing pharmacokinetics (PK), bioavailability and bioequivalence (BA/BE), toxicokinetics (TK), immunogenicity (ADA), biomarker testing, and custom assays. We are a GLP/GCLP compliant, FDA audited, and DEA & CT State Schedule II – IV approved facility that offers competitive pricing on all our products and services.
NorthEast BioLab has extensive experience in the design, development and validation of biopharmaceutical assays for clinical, preclinical and drug discovery studies. Our team offers LC-MS/MS method development and validation, as well as other technologies such as ELISA, MSD ECL, Luminex Multiplex, Western Blot and qPCR. We’re a GLP/GCLP compliant FDA audited and DEA & CT State Schedule II-IV approved facility to help you advance your pharmacokinetic testing with our scope of services.